Center of Reproductology / Blog / Sequencing of BRCA1,2 genes – determination of genetic predisposition to breast and ovarian cancer

Sequencing of BRCA1,2 genes – determination of genetic predisposition to breast and ovarian cancer

According to the latest research, the BRCA1 and BRCA2 genes are responsible for the occurrence of most types of hereditary oncopathologies of the breast and ovaries. A genetic test is now available at the ISIDA clinic to determine whether there is a mutation of these genes in the body.

According to medical statistics, up to 10% of all human cancers occur against the background of a genetic mutation that is inherited. Awareness of the presence of mutated genes in the body, which can lead to the occurrence of cancer, allows you to take timely measures and prevent the development of oncopathology.

By sequencing the BRCA1,2 genes, it is possible to exclude or confirm the presence of mutations of the BRCA1 and/or BRCA2 genes in the body. Medical statistics show that in the case of mutation of these genes, the risk of breast cancer in women by the age of 70 increases to 87%, ovarian cancer – up to 44%. For comparison, the risk of breast cancer in the general population is 12%, ovarian cancer is 1.3%.

5 Most Important Facts about BRCA1 and BRCA2 Gene Mutations

Pathogenic mutation BRCA1 or BRCA2 can be inherited by a child from both mother and father. The risk of transmission is 50%.

Mutations in the BRCA1 and BRCA2 genes, in addition to breast cancer and ovarian cancer, increase the risk of fallopian tube cancer and peritoneal cancer.

Mutations of the BRCA2 gene are dangerous not only for women, but also for men. The presence of mutations increases the risk of prostate cancer. In addition, both men and women with pathogenic BRCA1 or BRCA2 mutations have an increased risk of developing pancreatic cancer. Some mutations in BRCA2 (known as FANCD1), if inherited from both parents, can cause a rare form of Fanconi anemia, as well as the development of acute myeloid leukemia. Similarly, some mutations in BRCA1 (known as FANCS), if inherited from both parents, can cause another subtype of Fanconi anemia.

If genetic analysis shows the presence of a mutation in the BRCA1 or BRCA2 genes, this does not mean that cancer pathology is inevitable. The disease may simply not develop. In addition, modern medicine has quite effective methods to reduce the risk of cancer, even with a positive result for a mutation in the genes.

In order to reduce the risk of cancer in the presence of mutations in genes, modern medicine uses constant health monitoring, preventive surgical interventions and chemoprophylaxis.

How is the genetic analysis for the mutation of the BRCA1,2 genes carried out

To undergo a genetic analysis for the BRCA1,2 genes, you just need to donate blood. Having received negative test results, you can be sure that you do not have a hereditary genetic predisposition to breast cancer and / or ovarian cancer. If the test results are positive, your doctor will give you effective recommendations on how to avoid the occurrence of oncopathology.

ISIDA Clinic has been engaged in the diagnosis and treatment of a number of pathologies and diseases for almost 30 years, and every year we gain more and more experience and knowledge, and our specialists always strive to have as complete a picture as possible in order to choose the right treatment regimen. Therefore, here at ISIDA, we always achieve high results – thanks to the professionalism and diligence of our doctors and the level of modern technology. Trust the specialists of the ISIDA clinic!

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