/ / NGS at ISIDA



During the course of the IVF treatment, it is possible to eliminate the genetic disease of the child even before pregnancy. ISIDA Clinic has introduced a new high-precision technique: NGS.

How and where is it performed?

In the embryology laboratory. The cells begin to differentiate on the fifth day of embryo development. The tissues and organs are formed from the inner layer, whereas the outer layer, i.e. trophoblast is responsible for implantation and subsequently becomes the placenta. Any risk associated with embryo’s further development is minimized since the sample of material for the analysis is taken from the outer layer.

In the genetic center. This technique is called the Next Generation Sequencing or simply NGS (from the Latin word “sequentum” meaning “sequence”) and allows to decode the sequencing of the entire genome. The accuracy of the testing intended to identify any possible chromosomal and monogenic diseases is 99.9%. The process is entirely automated, and so the human factor gets fully eliminated.

In the doctor's office. Since embryos are able to survive in vitro only for five days and the analysis needs time, the cryo-cycle becomes an ultimate solution. Embryos are frozen ultrafast and then transferred into the uterus during the next cycle at the most appropriate time for conception. In such a manner, the doctors are able to prepare the woman’s body for the pregnancy, balance the hormones and make sure that endometrium is ready for implantation.

The procedure is indicated for…

Patients who are planning to get IVF, especially in a case of previous failed implantation or pregnancy attempts. Almost 50% of non-achieved pregnancies by IVF are due to genetic factors. It has been proved that the uterus is a sensitive biosensor which often rejects the embryo that has chromosomal disorders. So far, PGD with the use of NGS has been recognized to be the most effective method. It allows achieving high implantation rates, minimizing the risk of miscarriage and increasing the number of healthy babies.

Couples with increased risks of having a baby with genetic abnormalities. This chiefly applies to those who are carriers of abnormal genes and are aware of it. Another serious factor that must not be brushed off is the age. It has been established that the likelihood of chromosomal abnormalities increases as the woman gets older.

Expert Anton BROVKO, Biologist and Cytogeneticist in ISIDA Clinic:

"As of today, NGS is the most informative procedure for genetic testing, the innovativeness of which is emphasized by the name itself, i.e. the next-generation sequencing."