/ / Genetische Diagnostik

Genetische Diagnostik

PGD/PGS (PID – Präimplantationsdiagnostik) ist eine diagnostische Prozedur, die in jenen Fällen während der IVF (In-vitro-Fertilisation) angewendet wird, wenn der Fetus einem Risiko von genetischen oder anderen Krankheiten unterworfen ist. 

ISIDA war die erste Klinik, die genetisches Präimlimplantations-Screening – ein hochgenaues NGS-Verfahren, mit dem beliebige durch eine bekannte Genmutation verursachte genetische Krankheit erkannt werden kann, – in der Ukraine in die Praxis umgesetzt hat. Kennzeichnende Besonderheit des NGS-Verfahrens ist seine volle Automation. Dadurch werden die mit menschlichem Faktor verbundenen Risiken ausgeschlossen.

Die Methode NGS (Next Generation Sequencing) erhöht wesentlich den Erfolg der Programme der extrakorporalen Befruchtung, weil sie ermöglicht, noch bevor Implantation der Embryonen alle bekannten chromosomalen Pathologien  zu erkennen, die ungefähr in 50% der Fälle der Grund des Nichteintritts der Schwangerschaft im Programm sind.  

Wie wird die NGS-Diagnostik durchgeführt?

Am fünften Tag nach der Befruchtung beginnen sich die Zellen des Embryos in die „intrazelluläre Masse“ zu differenzieren,  aus der ein zukünftiges Kind formieren wird, und in die Zellen der Außenschicht–  Trophektodermis, die an der Implantation des Embryos in die Gebärmutterhöhle teilnehmen und die Plazenta bilden werden.

Für NGS-Analyse, indem man äußerst präzise Instrumente benutzt, nimmt man einige Zellen der Trophektodermis. Die Wahrscheinlichkeit der Verletzung des Embryos ist dabei minimal.  

Die für eine Analyse genommenen Zellen werden mittels der Methode NGS auf Vorhandensein der chromosomalen oder Genanomalien geprüft. Der Prozess der Diagnostik ist vollautomatisiert und ermöglicht jede genetische Erkrankung zu erkennen, die mit dem Vorhandensein der bekannten Genmutation verbunden ist. Die Genauigkeit des Ergebnisses nach der NGS – Methode beträgt 99,9%!

In Erwartung der Ergebnisse werden die Embryonen nach dem Verfahren der  Vitrifikation eingefroren, die Übertragung der diagnostizierten Embryonen wird im Kryozyklus durchgeführt, indem man das Risiko der Hyperstimulation eliminiert und den Erfolg der Implantation der Embryonen in die Gebärmutterhöhle erhöht.

Die Durchführung von PID wird in folgenden Fällen empfohlen:

  • Die Mutter ist älter als 35 Jahre;
  • Bei typischer Prämaturität;
  • In der Anamnese gibt es eine Schwangerschaft mit der Chromosomenstörung des Fötus;
  • Es hat einige unerfolgreiche IVF-Versuche gegeben;
  • Einer der Erzeuger hat eine Chromosomentranslokation.

Die moderne Diagnostik erlaubt uns, einen gesunden Embryo auszuwählen, bevor die Krankheit in Erscheinung tritt.

Außerdem lässt die PID uns, das Geschlecht des zukünftigen Kindes festzustellen.

 

Referenzen

Julie 7. Dezember 2018
Julie 7. Dezember 2018

ISIDA is a qualified European clinic! Thank you for being!

ISIDA is a qualified European clinic! Thank you for being!

Natalie 2. Dezember 2018
Natalie 2. Dezember 2018

Despite more than one year passed since my last visit to ISIDA clinic, words of appreciation do not have expiry date. I would like to express my appreciation to Kseniia Khazhylenko for being a master of her craft. Thank to het choosing individual IVF treatment program for me, I made it to carry pregnancy. I would also like to thank Kapshyk Irina for carrying out stimulation to its end and making successful transfer afterwards. Special thanks to Ulaeva Evgenia, who did her best, settled all the issues and made me believe in the positive result. I`m the happy Mother of the best daughter in the world now! We celebrate every minute of her presence in our life. In response to the surprised exclamations of our friends and doctors regarding her fast developing , we just smile. She is 5AA after all!

Despite more than one year passed since my last visit to ISIDA clinic, words of appreciation do not have expiry date. I would like to express my appreciation to Kseniia Khazhylenko for being a master of her craft. Thank to het choosing individual IVF treatment program for me, I made it to carry pregnancy. I would also like to thank Kapshyk Irina for carrying out stimulation to its end and making successful transfer afterwards. Special thanks to Ulaeva Evgenia, who did her best, settled all the issues and made me believe in the positive result. I`m the happy Mother of the best daughter in the world now! We celebrate every minute of her presence in our life. In response to the surprised exclamations of our friends and doctors regarding her fast developing , we just smile. She is 5AA after all!

Claire 24. November 2018
Claire 24. November 2018

My first treatment using donor eggs at Isida was successful with no problems. I then tried another 5 times with fresh & frozen embryos. The 5th attempt worked for me & I have two beautiful twin girls. Do not give up hope. Keep trying. Isida's pricing is very good & the staff, especially Anna are kind & helpful. I would hope to go back for another child.

My first treatment using donor eggs at Isida was successful with no problems. I then tried another 5 times with fresh & frozen embryos. The 5th attempt worked for me & I have two beautiful twin girls. Do not give up hope. Keep trying. Isida's pricing is very good & the staff, especially Anna are kind & helpful. I would hope to go back for another child.

Ivanna 19. November 2018
Ivanna 19. November 2018

A big thank you to the whole team of ISIDA for your professionalism. We are so grateful to you! You give people the most precious thing - life!

A big thank you to the whole team of ISIDA for your professionalism. We are so grateful to you! You give people the most precious thing - life!

Iryna 13. November 2018
Iryna 13. November 2018

Dear Doctor Svitlana Turbanist, From the bottom of my heart I would like to thank you and ISIDA clinic for the happiness that you gave me. Other doctors refused to help me but you made me happy. My son Nikolai is 4 months old now. I wish the best for you and the clinic. A huge thank you to you!

Dear Doctor Svitlana Turbanist, From the bottom of my heart I would like to thank you and ISIDA clinic for the happiness that you gave me. Other doctors refused to help me but you made me happy. My son Nikolai is 4 months old now. I wish the best for you and the clinic. A huge thank you to you!

Семья Татьяны Синиковой 12. November 2018
Семья Татьяны Синиковой 12. November 2018

Благодарим весь персонал Исиды! Оставайтесь такими, чтобы мы возвращались к Вам за новым счастьем. С огромной благодарностью высокопрофессиональному, высококвалифицированному коллективу клиники ISIDA от бесконечно счастливых родителей, бабушек и дедушек.

Благодарим весь персонал Исиды! Оставайтесь такими, чтобы мы возвращались к Вам за новым счастьем. С огромной благодарностью высокопрофессиональному, высококвалифицированному коллективу клиники ISIDA от бесконечно счастливых родителей, бабушек и дедушек.

Inna 7. November 2018
Inna 7. November 2018

Isida clinic has given us not one, but two babies! We did not expect it, but an ultrasound showed that we were blessed with two boys. Now we are worried doubly, but happy twice as much at the same time. We will be great parents of twins, no worries about that!

Isida clinic has given us not one, but two babies! We did not expect it, but an ultrasound showed that we were blessed with two boys. Now we are worried doubly, but happy twice as much at the same time. We will be great parents of twins, no worries about that!

Helen 2. November 2018
Helen 2. November 2018

The best clinic and the most caring doctors! The best memories. It's a place you want to come back to:)

The best clinic and the most caring doctors! The best memories. It's a place you want to come back to:)

Julia 22. Oktober 2018
Julia 22. Oktober 2018

ISIDA is a well-qualified European clinic! Thank you!

ISIDA is a well-qualified European clinic! Thank you!

Anna 18. Oktober 2018
Anna 18. Oktober 2018

Myroslava Vatsyk is a very good specialist. She explains everything so clearly and helps you think positively and do positive things.

Myroslava Vatsyk is a very good specialist. She explains everything so clearly and helps you think positively and do positive things.

Olga 15. Oktober 2018
Olga 15. Oktober 2018

We are truly grateful for our two sons. Thanks to Myroslava Vatsyk I managed to get pregnant with the help of IVF. From the very beginning you gave us hope and belief. Thank you.

We are truly grateful for our two sons. Thanks to Myroslava Vatsyk I managed to get pregnant with the help of IVF. From the very beginning you gave us hope and belief. Thank you.

Marina 13. Oktober 2018
Marina 13. Oktober 2018

Having been to many doctors and clinics (to help me with my situation, I was suggested donor oocyte and operation), I turned to Doctor Svitlana Turbanist. She was the only one who suggested medical treatment, and I got pregnant naturally, which I wasn't even hoping for! Doctor Svetlana gave our family a big miracle!! We are extremely grateful to this doctor for her professionalism and experience.

Having been to many doctors and clinics (to help me with my situation, I was suggested donor oocyte and operation), I turned to Doctor Svitlana Turbanist. She was the only one who suggested medical treatment, and I got pregnant naturally, which I wasn't even hoping for! Doctor Svetlana gave our family a big miracle!! We are extremely grateful to this doctor for her professionalism and experience.